Nucleator or not?

Nucleator or not?

Calcium channels SMA A paralyzing disease might best be treated by exciting motoneurons rather than saving them, report Jablonka et al. The paralysis that occurs in patients with spinal muscular atrophy (SMA) stems from defective SMN1, a protein that interacts with mRNA transport factors. Motoneurons seem to be particularly sensitive to the transport problems, perhaps due to their considerable ...

A prolific nucleator program

A prolific nucleator program n studies of Drosophila cells, aurora-A kinase and centrosomin (CNN) are sometimes used as markers for centrosomes, but, other than their localization, relatively little is known about these proteins. On page 757, Terada et al. show that aurora-A and CNN must physically interact to be translocated to the centro-some, and, once there, CNN acts as a powerful microtubu...

pre-coordination or not?

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Actin Cytoskeleton: A Nucleator Face-Off

Actin assembly proteins initiate the formation of diverse cytoskeletal structures in a single cell. A new study shows that assembly factors compete for actin monomers, leading to homeostasis between different actin networks.

Folic Acid Supplementation: to Advise or not to Advise?